Cuba is different from the other programmes here in structure: it prohibits by default and permits by licence, rather than blocking listed persons.
How the prohibition is written
31 CFR 515.201 prohibits, “except as specifically authorized”, transactions by, on behalf of, or at the direction of a designated foreign country or any national of it, and transactions involving property in which that country or a national has at any time had “any interest of any nature whatsoever, direct or indirect”. It names transfers of credit and payments through any banking institution wherever located involving property subject to US jurisdiction, foreign exchange transactions, and the export or withdrawal of gold, silver, currency or securities.
The regulations date from 9 July 1963 (28 FR 6974). Their authority line shows how many layers have been added since: the Trading with the Enemy Act, a 1948 executive order, a 1962 proclamation, a 1993 executive order, and several later statutes. A reader working on a Cuba question is reading a regulation that has been amended for more than sixty years, not one drafted for the present.
Why the structure matters
Because the test is an interest “of any nature whatsoever, direct or indirect”, the analysis is closer to a property-interest question than a list-match. An entity that appears on no list can still be caught if a Cuban national holds an interest in the transaction. That is the opposite of the position under the fifty percent rule, which sets a numerical threshold, and it is why a screening approach built only on names is weakest here.
The page records the legal structure only. The detailed exemptions, general licences and category-specific rules change often and should be read on OFAC’s own Cuba pages, linked from the sources list.